8SIF

Crystal structure of Escherichia coli HPPK in complex with bisubstrate inhibitor HP-101

8SIF の概要

• エントリーDOI: 10.2210/pdb8sif/pdb
• 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-{(2R,4R)-1-[3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]-2-carboxypiperidin-4-yl}-5'-thioadenosine (3 entities in total)
• 機能のキーワード: hppk, bisubstrate inhibitor, hp-101, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18698.38

構造登録者

Shaw, G.X.,Shi, G.,Ji, X. (登録日: 2023-04-16, 公開日: 2024-07-03)

• 主引用文献: Shi, G.,Shaw, G.X.,Ji, X.; The first bisubstrate inhibitor of HPPK exhibiting cell permeability; To be published,

実験手法

X-RAY DIFFRACTION (1.7 Å)