8SEL

Type IIIb beta-amyloid 40 Filaments from Down Syndrome

8SEL の概要

• エントリーDOI: 10.2210/pdb8sel/pdb
• EMDBエントリー: 40421
• 分子名称: Amyloid-beta protein 40 (1 entity in total)
• 機能のキーワード: beta amyloid filaments, down syndrome, neuropeptide, human trisomy 21
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 20
• 化学式量合計: 86717.04

構造登録者

Hoq, M.R.,Vago, F.S.,Bharath, S.R.,Jiang, W. (登録日: 2023-04-10, 公開日: 2024-04-03, 最終更新日: 2024-06-26)

主引用文献

Fernandez, A.,Hoq, M.R.,Hallinan, G.I.,Li, D.,Bharath, S.R.,Vago, F.S.,Zhang, X.,Ozcan, K.A.,Newell, K.L.,Garringer, H.J.,Jiang, W.,Ghetti, B.,Vidal, R.
Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31:903-909, 2024

PubMed Abstract: Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS and AD regarding the structure of amyloid-β (Aβ) and tau filaments is unknown. Here we report the structure of Aβ and tau filaments from two DS brains. We found two Aβ filaments (types IIIa and IIIb) that differ from those previously reported in sporadic AD and two types of Aβ filaments (I and II) identical to those found in sporadic and familial AD. Tau filaments (paired helical filaments and straight filaments) were identical to those in AD, supporting the notion of a common mechanism through which amyloids trigger aggregation of tau. This knowledge is important for understanding AD in DS and assessing whether adults with DS could be included in AD clinical trials.

PubMed: 38553642
DOI: 10.1038/s41594-024-01252-3

実験手法

ELECTRON MICROSCOPY (3.8 Å)