8SDV

Crystal structure of PDC-3 Y221H beta-lactamase in complex with the boronic acid inhibitor S02030

Summary for 8SDV

Entry DOI	10.2210/pdb8sdv/pdb
Descriptor	Beta-lactamase, IMIDAZOLE, 1-{(2R)-2-(dihydroxyboranyl)-2-[(thiophen-2-ylacetyl)amino]ethyl}-1H-1,2,3-triazole-4-carboxylic acid, ... (5 entities in total)
Functional Keywords	pseudomonas-derived cephalosporinase, antibiotic resistance, hydrolase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	1
Total formula weight	44090.86
Authors	Kumar, V.,van den Akker, F. (deposition date: 2023-04-07, release date: 2023-08-16, Last modification date: 2023-11-22)
Primary citation	Mack, A.R.,Kumar, V.,Taracila, M.A.,Mojica, M.F.,O'Shea, M.,Schinabeck, W.,Silver, G.,Hujer, A.M.,Papp-Wallace, K.M.,Chen, S.,Haider, S.,Caselli, E.,Prati, F.,van den Akker, F.,Bonomo, R.A. Natural protein engineering in the Omega-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas -derived cephalosporinase. Antimicrob.Agents Chemother., 67:e0079123-e0079123, 2023 Cited by PubMed: 37850746 DOI: 10.1128/aac.00791-23 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation