8SBI

Crystal structure of human sterol 14 alpha-demethylase (CYP51) in the ligand-free state

8SBI の概要

• エントリーDOI: 10.2210/pdb8sbi/pdb
• 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
• 機能のキーワード: monooxygenase, cytochrome p450, endoplasmic reticulum, sterol biosynthesis, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 104587.68

構造登録者

Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (登録日: 2023-04-03, 公開日: 2023-04-12, 最終更新日: 2025-06-25)

• 主引用文献: Hargrove, T.Y.,Lamb, D.C.,Wawrzak, Z.,Minasov, G.,Goldstone, J.V.,Kelly, S.L.,Stegeman, J.J.,Lepesheva, G.I.; Unique Structural Features Relate to Evolutionary Adaptation of Cytochrome P450 in the Abyssal Zone; Int J Mol Sci, 26:-, 2025; DOI: 10.3390/ijms26125689

実験手法

X-RAY DIFFRACTION (2.73 Å)