8S9K

Structure of dimeric FAM111A SPD S541A Mutant

Summary for 8S9K

Entry DOI	10.2210/pdb8s9k/pdb
Descriptor	Serine protease FAM111A, GLYCEROL (3 entities in total)
Functional Keywords	protease, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	127521.05
Authors	Palani, S.,Alvey, J.A.,Cong, A.T.Q.,Schellenberg, M.J.,Machida, Y. (deposition date: 2023-03-29, release date: 2024-03-20)
Primary citation	Palani, S.,Machida, Y.,Alvey, J.R.,Mishra, V.,Welter, A.L.,Cui, G.,Bragantini, B.,Botuyan, M.V.,Cong, A.T.Q.,Mer, G.,Schellenberg, M.J.,Machida, Y.J. Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes. Nat Commun, 15:2064-2064, 2024 Cited by PubMed: 38453899 DOI: 10.1038/s41467-024-46207-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.72 Å)

Structure validation