8S9H

Crystal structure of monkey TLR7 ectodomain with compound 14

8S9H の概要

• エントリーDOI: 10.2210/pdb8s9h/pdb
• 分子名称: Toll-like receptor 7, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: toll-like receptor 7, pattern recognition receptor, immune system, agonist
• 由来する生物種: Macaca mulatta (Rhesus monkey)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 194255.46

構造登録者

Critton, D.A. (登録日: 2023-03-28, 公開日: 2024-02-07, 最終更新日: 2024-02-28)

• 主引用文献: He, L.,Zhang, M.Y.,Cox, M.,Zhang, Q.,Donnell, A.F.,Zhang, Y.,Tarby, C.,Gill, P.,Subbaiah, M.A.M.,Ramar, T.,Reddy, M.,Puttapaka, V.,Li, Y.X.,Sivaprakasam, P.,Critton, D.,Mulligan, D.,Xie, C.,Ramakrishnan, R.,Nagar, J.,Dudhgaonkar, S.,Murtaza, A.,Oderinde, M.S.,Schieven, G.L.,Mathur, A.,Gavai, A.V.,Vite, G.,Gangwar, S.,Poudel, Y.B.; Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.; Acs Med.Chem.Lett., 15:189-196, 2024; PubMed: 38352849; DOI: 10.1021/acsmedchemlett.3c00456

実験手法

X-RAY DIFFRACTION (2.437 Å)