8S8X

SARS-CoV-2 nsp10-16 methyltransferase in complex with Toyocamycin and m7GpppA-RNA (Cap0-RNA)

8S8X の概要

• エントリーDOI: 10.2210/pdb8s8x/pdb
• 関連するPDBエントリー: 8BSD 8BZV 8C5M 8OSX 8OT0 8OTR 8OV1
• 分子名称: 2'-O-methyltransferase nsp16, Non-structural protein 10, m7GpppA-RNA (Cap0-RNA), ... (9 entities in total)
• 機能のキーワード: methyltransferase, complex, inhibitor, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 51335.72

構造登録者

Kremling, V.,Sprenger, J.,Oberthuer, D.,Scheer, T.E.S. (登録日: 2024-03-07, 公開日: 2024-03-20, 最終更新日: 2024-11-13)

• 主引用文献: Kremling, V.,Falke, S.,Fernandez-Garcia, Y.,Ehrt, C.,Kiene, A.,Klopprogge, B.,Scheer, E.,Barthels, F.,Middendorf, P.,Kuhn, S.,Gunther, S.,Rarey, M.,Chapman, H.N.,Oberthur, D.,Sprenger, J.; SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery; Elife, 2024; DOI: 10.7554/elife.98310.1

実験手法

X-RAY DIFFRACTION (1.99 Å)