8S8C

Structure of Kras in complex with inhibitor MK-1084

This is a non-PDB format compatible entry.

Summary for 8S8C

• Entry DOI: 10.2210/pdb8s8c/pdb
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: nucleotide binding, gtpase, hydrolase, signal transduction, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 20459.38

Authors

Day, P.J.,Cleasby, A. (deposition date: 2024-03-06, release date: 2024-07-10, Last modification date: 2024-07-24)

• Primary citation: Ma, X.,Sloman, D.L.,Duggal, R.,Anderson, K.D.,Ballard, J.E.,Bharathan, I.,Brynczka, C.,Gathiaka, S.,Henderson, T.J.,Lyons, T.W.,Miller, R.,Munsell, E.V.,Orth, P.,Otte, R.D.,Palani, A.,Rankic, D.A.,Robinson, M.R.,Sather, A.C.,Solban, N.,Song, X.S.,Wen, X.,Xu, Z.,Yang, Y.,Yang, R.,Day, P.J.,Stoeck, A.,Bennett, D.J.,Han, Y.; Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRAS G12C Inhibitor.; J.Med.Chem., 67:11024-11052, 2024; PubMed: 38924388; DOI: 10.1021/acs.jmedchem.4c00572

Experimental method

X-RAY DIFFRACTION (1.9 Å)