8S6Z

CD28 in complex with the antibody Fab fragment AI3

Summary for 8S6Z

Entry DOI	10.2210/pdb8s6z/pdb
Descriptor	Heavy chain Fab fragment of AI3 antibody, Light chain of AI3 antibody, T-cell-specific surface glycoprotein CD28, ... (9 entities in total)
Functional Keywords	antibody, complex, cd28, immune system
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	130832.75
Authors	Majocchi, S.,Giovanni, M.,Malinge, P.,Fischer, N.,Svensson, L.A.,Kelpsas, V.,Rose, N.C. (deposition date: 2024-02-28, release date: 2024-12-18)
Primary citation	Majocchi, S.,Giovanni, M.,Malinge, P.,Fischer, N.,Svensson, L.A.,Kelpsas, V. NI-3201 is a bispecific antibody mediating PD-L1-dependent CD28 costimulation on T cells for enhanced tumor control Cancer Immunology Research, 2024 Cited by DOI: 10.1158/2326-6066.CIR-24-0298 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.05 Å)

Structure validation