8S30

Crystal structure of human PLK1 Polo-Box Domain in complex with Mis18

Summary for 8S30

• Entry DOI: 10.2210/pdb8s30/pdb
• Descriptor: Serine/threonine-protein kinase PLK1, Protein Mis18-alpha (3 entities in total)
• Functional Keywords: plk1, mis18 complex, centromere, chromosome missegregation, cell cycle
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 28756.71

Authors

Jeyaprakash, A.A.,Medina-Pritchard, B. (deposition date: 2024-02-19, release date: 2024-08-21)

• Primary citation: Jeyaprakash, A.A.,Medina-Pritchard, B.; PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance; Science, 2024; DOI: 10.1126/science.ado8270

Experimental method