8S30

Crystal structure of human PLK1 Polo-Box Domain in complex with Mis18

Summary for 8S30

Entry DOI	10.2210/pdb8s30/pdb
Descriptor	Serine/threonine-protein kinase PLK1, Protein Mis18-alpha (3 entities in total)
Functional Keywords	plk1, mis18 complex, centromere, chromosome missegregation, cell cycle
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	28756.71
Authors	Jeyaprakash, A.A.,Medina-Pritchard, B. (deposition date: 2024-02-19, release date: 2024-08-21, Last modification date: 2024-09-18)
Primary citation	Parashara, P.,Medina-Pritchard, B.,Abad, M.A.,Sotelo-Parrilla, P.,Thamkachy, R.,Grundei, D.,Zou, J.,Spanos, C.,Kumar, C.N.,Basquin, C.,Das, V.,Yan, Z.,Al-Murtadha, A.A.,Kelly, D.A.,McHugh, T.,Imhof, A.,Rappsilber, J.,Jeyaprakash, A.A. PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance. Science, 385:1098-1104, 2024 Cited by PubMed: 39236175 DOI: 10.1126/science.ado8270 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation