8S1A

c-KIT kinase domain in complex with crenolanib

Summary for 8S1A

• Entry DOI: 10.2210/pdb8s1a/pdb
• Descriptor: Mast/stem cell growth factor receptor Kit, 1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine (3 entities in total)
• Functional Keywords: stem cell factor receptor, inhibitor, gist, resistance, kit, crenolanib, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 75275.94

Authors

Teuber, A.,Mueller, M.P.,Rauh, D. (deposition date: 2024-02-15, release date: 2025-09-03)

• Primary citation: Teuber, A.,Niggenaber, J.,Kleinboelting, S.B.,Landel, I.,Warmuth, J.,Busick, D.,Mueller, M.P.,Bauer, S.,Rauh, D.; c-KIT kinase domain in complex with crenolanib; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)