8RY2

Crystal Structure of ANV419, a novel IL-2/anti-IL-2 antibody fusion protein

Summary for 8RY2

• Entry DOI: 10.2210/pdb8ry2/pdb
• Descriptor: ANV419 heavy-chain, ANV419 light-chain (3 entities in total)
• Functional Keywords: immuno-oncology, cytokine
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 126496.00

Authors

Rondeau, J.M.,Wirth, E. (deposition date: 2024-02-08, release date: 2024-07-31)

• Primary citation: Murer, P.,Brannetti, B.,Rondeau, J.M.,Petersen, L.,Egli, N.,Popp, S.,Regnier, C.,Richter, K.,Katopodis, A.,Huber, C.; Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy.; Mabs, 16:2381891-2381891, 2024; PubMed: 39041287; DOI: 10.1080/19420862.2024.2381891

Experimental method

X-RAY DIFFRACTION (2.05 Å)