Summary for 8RX9
Entry DOI | 10.2210/pdb8rx9/pdb |
Related | 8RX7 |
Descriptor | Leukotriene A-4 hydrolase, ZINC ION, ACETATE ION, ... (7 entities in total) |
Functional Keywords | lta4h, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 70577.14 |
Authors | Srinivas, H. (deposition date: 2024-02-06, release date: 2024-03-20, Last modification date: 2024-04-10) |
Primary citation | Thoma, G.,Miltz, W.,Srinivas, H.,Penno, C.A.,Kiffe, M.,Gajewska, M.,Klein, K.,Evans, A.,Beerli, C.,Rohn, T.A. Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor. J.Med.Chem., 67:5093-5108, 2024 Cited by PubMed: 38476002DOI: 10.1021/acs.jmedchem.4c00290 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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