8RX9

LTA4 hydrolase in complex with compound3

This is a non-PDB format compatible entry.

Summary for 8RX9

• Entry DOI: 10.2210/pdb8rx9/pdb
• Related: 8RX7
• Descriptor: Leukotriene A-4 hydrolase, ZINC ION, ACETATE ION, ... (7 entities in total)
• Functional Keywords: lta4h, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 70577.14

Authors

Srinivas, H. (deposition date: 2024-02-06, release date: 2024-03-20, Last modification date: 2024-04-10)

• Primary citation: Thoma, G.,Miltz, W.,Srinivas, H.,Penno, C.A.,Kiffe, M.,Gajewska, M.,Klein, K.,Evans, A.,Beerli, C.,Rohn, T.A.; Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor.; J.Med.Chem., 67:5093-5108, 2024; PubMed: 38476002; DOI: 10.1021/acs.jmedchem.4c00290

Experimental method

X-RAY DIFFRACTION (2.9 Å)