8RX0

(NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub

Summary for 8RX0

• Entry DOI: 10.2210/pdb8rx0/pdb
• EMDB information: 19567
• Descriptor: von Hippel-Lindau disease tumor suppressor, (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, ZINC ION, ... (12 entities in total)
• Functional Keywords: ubiquitin, cullin, ring, e2 complex, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 221361.99

Authors

Crowe, C.,Nakasone, M.A. (deposition date: 2024-02-05, release date: 2024-03-06)

• Primary citation: Crowe, C.,Nakasone, M.A.; (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.7 Å)