8RO6

Human cohesin SMC1A-HD(longCC)/RAD21-C complex - Apo closed P-loop conformation

8RO6 の概要

• エントリーDOI: 10.2210/pdb8ro6/pdb
• 分子名称: Structural maintenance of chromosomes protein 1A (SMC1A), 64-kDa C-terminal product (3 entities in total)
• 機能のキーワード: 3d genome organization, chromatin, cohesin, atpase activity, atpase cycle, nuclear protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60647.88

構造登録者

Shaik, T.B.,Romier, C. (登録日: 2024-01-11, 公開日: 2024-09-11, 最終更新日: 2024-09-18)

• 主引用文献: Vitoria Gomes, M.,Landwerlin, P.,Diebold-Durand, M.L.,Shaik, T.B.,Durand, A.,Troesch, E.,Weber, C.,Brillet, K.,Lemee, M.V.,Decroos, C.,Dulac, L.,Antony, P.,Watrin, E.,Ennifar, E.,Golzio, C.,Romier, C.; The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains.; Cell Rep, 43:114656-114656, 2024; PubMed: 39240714; DOI: 10.1016/j.celrep.2024.114656

実験手法

X-RAY DIFFRACTION (2.2 Å)