8RKY

X-ray structure of the drug binding domain of AlbA in complex with the KMR-14-14 compound of the pyrrolobenzodiazepines class

This is a non-PDB format compatible entry.

Summary for 8RKY

• Entry DOI: 10.2210/pdb8rky/pdb
• Descriptor: Albicidin resistance protein, ethyl 4-[[5-[[4-[4-[[(6~{a}~{S})-2-methoxy-11-oxidanylidene-6~{a},7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]butanoylamino]-1-methyl-pyrrol-2-yl]carbonylamino]-1-benzothiophen-2-yl]carbonylamino]-1-methyl-imidazole-2-carboxylate, ~{S}-[(2~{S},3~{S})-2,3-bis(oxidanyl)-4-sulfanyl-butyl] 4-[[5-[[4-[4-[[(6~{a}~{S})-2-methoxy-11-oxidanylidene-6~{a},7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]butanoylamino]-1-methyl-pyrrol-2-yl]carbonylamino]-1-benzothiophen-2-yl]carbonylamino]-1-methyl-imidazole-2-carbothioate, ... (5 entities in total)
• Functional Keywords: drug binding, bacterial resistance, pyrrolobenzodiazepines, dna binding protein
• Biological source: Klebsiella oxytoca
• Total number of polymer chains: 3
• Total formula weight: 83608.42

Authors

Di Palma, M.,Surani, Y.M.,Rahman, K.M.,Steiner, R.A. (deposition date: 2024-01-01, release date: 2025-01-15)

• Primary citation: Di Palma, M.,Surani, Y.M.,Rahman, K.M.,Steiner, R.A.; X-ray structure of the drug binding domain of AlbA in complex with the KMR-14-14 compound of the pyrrolobenzodiazepines class; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.17 Å)