8RKR

Structure of human DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (ALDH4A1) complexed with a monophosphate-tweezer

This is a non-PDB format compatible entry.

Summary for 8RKR

• Entry DOI: 10.2210/pdb8rkr/pdb
• Related: 8RKQ
• Descriptor: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, (1R,5S,9S,16R,20R,24S,28S,35R)-22-(Dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaen-3-ol, BENZOIC ACID, ... (4 entities in total)
• Functional Keywords: aldehyde dehydrogenase, aldh4a1, rossmann fold, oxidoreductase, nad, molecular tweezer, supramolecular ligands, protein-protein interactions
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 125435.90

Authors

Porfetye, A.T.,Vetter, I.R. (deposition date: 2023-12-28, release date: 2024-05-08)

• Primary citation: Porfetye, A.T.,Stege, P.,Rebollido-Rios, R.,Hoffmann, D.,Schrader, T.,Vetter, I.R.; How Do Molecular Tweezers Bind to Proteins? Lessons from X-ray Crystallography.; Molecules, 29:-, 2024; PubMed: 38675584; DOI: 10.3390/molecules29081764

Experimental method

X-RAY DIFFRACTION (1.2 Å)