8RKQ

Structure of human DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (ALDH4A1) complexed with the molecular tweezer CLR01

Summary for 8RKQ

Entry DOI	10.2210/pdb8rkq/pdb
Descriptor	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene (3 entities in total)
Functional Keywords	aldehyde dehydrogenase, aldh4a1, rossmann fold, oxidoreductase, nad, molecular tweezer, supramolecular ligands, protein-protein interactions
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	249328.15
Authors	Porfetye, A.T.,Vetter, I.R. (deposition date: 2023-12-28, release date: 2024-05-08)
Primary citation	Porfetye, A.T.,Stege, P.,Rebollido-Rios, R.,Hoffmann, D.,Schrader, T.,Vetter, I.R. How Do Molecular Tweezers Bind to Proteins? Lessons from X-ray Crystallography. Molecules, 29:-, 2024 Cited by PubMed: 38675584 DOI: 10.3390/molecules29081764 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation