8RH2

Trimeric HSV-2G gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules.

Summary for 8RH2

• Entry DOI: 10.2210/pdb8rh2/pdb
• EMDB information: 19163 19164 19165 19166
• Descriptor: Envelope glycoprotein B, HDIT102 Fab heavy chain, HDIT102 Fab light chain (3 entities in total)
• Functional Keywords: ectodomain, post-fusion, fab molecule, trimeric, viral protein
• Biological source: Human herpesvirus 2 strain G; More
• Total number of polymer chains: 9
• Total formula weight: 453277.17

Authors

Kalbermatter, D.,Seyfizadeh, N.,Imhof, T.,Ries, M.,Mueller, C.,Jenner, L.,Blumenschein, E.,Yendrzheyevskiy, A.,Moog, K.,Eckert, D.,Engel, R.,Diebolder, P.,Chami, M.,Krauss, J.,Schaller, T.,Arndt, M. (deposition date: 2023-12-14, release date: 2024-06-19)

• Primary citation: Seyfizadeh, N.,Kalbermatter, D.,Imhof, T.,Ries, M.,Muller, C.,Jenner, L.,Blumenschein, E.,Yendrzheyevskiy, A.,Grun, F.,Moog, K.,Eckert, D.,Engel, R.,Diebolder, P.,Chami, M.,Krauss, J.,Schaller, T.,Arndt, M.; Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus.; J.Biomed.Sci., 31:56-56, 2024; PubMed: 38807208; DOI: 10.1186/s12929-024-01045-2

Experimental method