8RDT
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with spiro-isoxazol based compound 8j
This is a non-PDB format compatible entry.
Summary for 8RDT
Entry DOI | 10.2210/pdb8rdt/pdb |
Descriptor | Cereblon isoform 4, ZINC ION, (5~{S})-3-(2,3,4-trimethoxyphenyl)-1-oxa-2,9-diazaspiro[4.5]dec-2-ene-8,10-dione, ... (5 entities in total) |
Functional Keywords | cereblon, ubiquitination, e3, molecular glue, spiro-isoxazole, signaling protein |
Biological source | Magnetospirillum gryphiswaldense |
Total number of polymer chains | 3 |
Total formula weight | 42070.58 |
Authors | |
Primary citation | Shevalev, R.,Bischof, L.,Sapegin, A.,Bunev, A.,Olga, G.,Kantin, G.,Kalinin, S.,Hartmann, M.D. Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode. Eur.J.Med.Chem., 270:116328-116328, 2024 Cited by PubMed: 38552426DOI: 10.1016/j.ejmech.2024.116328 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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