8RCW

Crystal structure of the Mycobacterium tuberculosis regulator VirS (N-terminal fragment 4-208) in complex with the lead compound SMARt751

8RCW の概要

• エントリーDOI: 10.2210/pdb8rcw/pdb
• 分子名称: HTH-type transcriptional regulator VirS, 4,4,4-tris(fluoranyl)-1-[4-(4-fluorophenyl)piperidin-1-yl]butan-1-one (3 entities in total)
• 機能のキーワード: arac family, transcription, tuberculosis, dna binding protein, in situ proteolysis
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51242.45

構造登録者

Grosse, C.,Sigoillot, M.,Megalizzi, V.,Tanina, A.,Willand, N.,Baulard, A.R.,Wintjens, R. (登録日: 2023-12-07, 公開日: 2024-04-10)

• 主引用文献: Grosse, C.,Sigoillot, M.,Megalizzi, V.,Tanina, A.,Willand, N.,Baulard, A.R.,Wintjens, R.; Crystal structure of the Mycobacterium tuberculosis VirS regulator reveals its interaction with the lead compound SMARt751.; J.Struct.Biol., 216:108090-108090, 2024; PubMed: 38548139; DOI: 10.1016/j.jsb.2024.108090

実験手法

X-RAY DIFFRACTION (1.692 Å)