8RBC

p53-Y220C Core Domain Covalently Bound to 3-amino-5-chloropyrazine-2,6-dicarbonitrile Soaked at 5 mM

Summary for 8RBC

• Entry DOI: 10.2210/pdb8rbc/pdb
• Related: 8RBA 8RBB
• Descriptor: Cellular tumor antigen p53, 3-azanylpyrazine-2,6-dicarbonitrile, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total)
• Functional Keywords: covalent, snar, stabilization, cell cycle
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 50448.84

Authors

Stahlecker, J.,Klett, T.,Stehle, T.,Boeckler, F.M. (deposition date: 2023-12-04, release date: 2024-11-27)

• Primary citation: Klett, T.,Stahlecker, J.,Jaag, S.,Masberg, B.,Knappe, C.,Lammerhofer, M.,Coles, M.,Stehle, T.,Boeckler, F.M.; Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution; Acs Pharmacol Transl Sci, 2024; DOI: 10.1021/acsptsci.4c00414

Experimental method

X-RAY DIFFRACTION (2.06 Å)