8RAK

Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-isopropyl-5-methyl-4-(pyridin-4-yloxy)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

8RAK の概要

• エントリーDOI: 10.2210/pdb8rak/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
• 機能のキーワード: drug discovery, dhodh, inhibitor, leukemia, protein binding, flavoprotein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44138.65

構造登録者

Alberti, M.,Miggiano, R. (登録日: 2023-12-01, 公開日: 2024-06-19)

• 主引用文献: Alberti, M.,Poli, G.,Broggini, L.,Sainas, S.,Rizzi, M.,Boschi, D.,Ferraris, D.M.,Martino, E.,Ricagno, S.,Tuccinardi, T.,Lolli, M.L.,Miggiano, R.; An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent.; Acta Crystallogr D Struct Biol, 80:386-396, 2024; PubMed: 38805244; DOI: 10.1107/S2059798324004066

実験手法

X-RAY DIFFRACTION (1.85 Å)