8R9U

A soakable crystal form of human CDK7 in complex with AMP-PNP

Summary for 8R9U

Entry DOI	10.2210/pdb8r9u/pdb
Descriptor	Cyclin-dependent kinase 7, 7-dimethylphosphoryl-3-[2-[[(3~{S})-6,6-dimethylpiperidin-3-yl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]-1~{H}-indole-6-carbonitrile (3 entities in total)
Functional Keywords	serine-threonine kinase, phosphorylation, cell cycle progression, atp binding, cell cycle
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	85452.20
Authors	Mukherjee, M.,Cleasby, A. (deposition date: 2023-11-30, release date: 2024-05-29, Last modification date: 2024-06-26)
Primary citation	Mukherjee, M.,Day, P.J.,Laverty, D.,Bueren-Calabuig, J.A.,Woodhead, A.J.,Griffiths-Jones, C.,Hiscock, S.,East, C.,Boyd, S.,O'Reilly, M. Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design. Structure, 2024 Cited by PubMed: 38870939 DOI: 10.1016/j.str.2024.05.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.937 Å)

Structure validation