8R9U

A soakable crystal form of human CDK7 in complex with AMP-PNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000439	cellular_component	transcription factor TFIIH core complex
A	0001650	cellular_component	fibrillar center
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005675	cellular_component	transcription factor TFIIH holo complex
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006468	biological_process	protein phosphorylation
A	0006974	biological_process	DNA damage response
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0042795	biological_process	snRNA transcription by RNA polymerase II
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050821	biological_process	protein stabilization
A	0051301	biological_process	cell division
A	0051726	biological_process	regulation of cell cycle
A	0070516	cellular_component	CAK-ERCC2 complex
A	0070985	cellular_component	transcription factor TFIIK complex
A	0106310	molecular_function	protein serine kinase activity
A	0140836	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 kinase activity
A	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
B	0000166	molecular_function	nucleotide binding
B	0000439	cellular_component	transcription factor TFIIH core complex
B	0001650	cellular_component	fibrillar center
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005675	cellular_component	transcription factor TFIIH holo complex
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006289	biological_process	nucleotide-excision repair
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006468	biological_process	protein phosphorylation
B	0006974	biological_process	DNA damage response
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0042795	biological_process	snRNA transcription by RNA polymerase II
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050821	biological_process	protein stabilization
B	0051301	biological_process	cell division
B	0051726	biological_process	regulation of cell cycle
B	0070516	cellular_component	CAK-ERCC2 complex
B	0070985	cellular_component	transcription factor TFIIK complex
B	0106310	molecular_function	protein serine kinase activity
B	0140836	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 kinase activity
B	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGQFATVYkArdkntnqiv.........AIKK

Chain	Residue	Details
A	LEU18-LYS42

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKpnNLLL

Chain	Residue	Details
A	ILE133-LEU145

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CDK1 and CDK2","evidences":[{"source":"PubMed","id":"11113184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9832506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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