8R99
A soakable crystal form of human CDK7 in complex with AMP-PNP
Summary for 8R99
| Entry DOI | 10.2210/pdb8r99/pdb |
| Descriptor | Cyclin-dependent kinase 7, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | serine-threonine kinase, phosphorylation, cell cycle progression, atp binding, cell cycle |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 42766.14 |
| Authors | Mukherjee, M.,Cleasby, A. (deposition date: 2023-11-30, release date: 2024-05-29, Last modification date: 2024-06-26) |
| Primary citation | Mukherjee, M.,Day, P.J.,Laverty, D.,Bueren-Calabuig, J.A.,Woodhead, A.J.,Griffiths-Jones, C.,Hiscock, S.,East, C.,Boyd, S.,O'Reilly, M. Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design. Structure, 2024 Cited by PubMed: 38870939DOI: 10.1016/j.str.2024.05.011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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