8R7E

MutSbeta bound to compound CHDI-00898647 in the canonical DNA-mismatch bound form

Summary for 8R7E

• Entry DOI: 10.2210/pdb8r7e/pdb
• Descriptor: DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, DNA (5'-D(*TP*CP*TP*AP*TP*CP*TP*GP*AP*AP*GP*CP*CP*GP*AP*TP*CP*GP*AP*TP*GP*G)-3'), ... (10 entities in total)
• Functional Keywords: proteros biostructures gmbh, dna binding protein, dna mismatch repair
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 449612.30

Authors

Thomsen, M.,Thieulin-Pardo, G.,Steinbacher, S.,Brace, G.,Tillack, K.,Johnson, P.,Ritzefeld, M.,Schaertl, S.,Frush, E.,Warfield, B.,Ballantyne, G.,Lee, J.-H.,Witte, D.,Finley, M.,Prasad, B.,Monteagudo, E.,Plotnikov, N.,Pacifici, R.,Maillard, M.,Wilkinson, H.,Iyer, R.,Dominguez, C.,Vogt, T.,Felsenfeld, D.,Haque, T. (deposition date: 2023-11-24, release date: 2024-11-27)

• Primary citation: Brace, G.,Tillack, K.,Johnson, P.,Ritzefeld, M.,Schaertl, S.,Frush, E.,Warfield, B.,Ballantyne, G.,Lee, J.-H.,Thieulin-Pardo, G.,Steinbacher, S.,Thomsen, M.,Witte, D.,Finley, M.,Prasad, B.,Monteagudo, E.,Plotnikov, N.,Pacifici, R.,Maillard, M.,Wilkinson, H.,Iyer, R.,Dominguez, C.,Vogt, T.,Felsenfeld, D.,Haque, T.; Identification of orthosteric inhibitors of MutSbeta ATPase function; Chemrxiv, 2024; DOI: 10.26434/chemrxiv-2024-74zr6

Experimental method

X-RAY DIFFRACTION (2.783 Å)