8R6J

Crystal structure of Candida glabrata Bdf1 bromodomain 1 bound to a pyrazole ligand

Summary for 8R6J

• Entry DOI: 10.2210/pdb8r6j/pdb
• Descriptor: Candida glabrata strain CBS138 chromosome C complete sequence, 2-methyl-~{N}-[[5-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)thiophen-2-yl]methyl]pyrazole-3-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: bromodomain, transcription
• Biological source: Nakaseomyces glabratus
• Total number of polymer chains: 2
• Total formula weight: 26833.13

Authors

Petosa, C.,Wei, K.,McKenna, C.E.,Govin, J. (deposition date: 2023-11-22, release date: 2024-10-30)

• Primary citation: Wei, K.,Arlotto, M.,Overhulse, J.M.,Dinh, T.A.,Zhou, Y.,Dupper, N.J.,Yang, J.,Kashemirov, B.A.,Dawi, H.,Garnaud, C.,Bourgine, G.,Mietton, F.,Champleboux, M.,Larabi, A.,Hayat, Y.,Indorato, R.L.,Noirclerc-Savoye, M.,Skoufias, D.,Cornet, M.,Rabut, G.,McKenna, C.E.,Petosa, C.,Govin, J.; Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors with Antifungal Potential against invasive Candida infection; Advanced Science, 2024

Experimental method

X-RAY DIFFRACTION (1.82 Å)