8R5V

Crystal structure of bovine pancreatic ribonuclease A in complex with [Sp-PS]-mU-dT dinucleotide

8R5V の概要

• エントリーDOI: 10.2210/pdb8r5v/pdb
• 分子名称: Ribonuclease pancreatic, 1-[(2~{R},4~{S},5~{R})-5-[[[(2~{R},6~{S})-2-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-6-(hydroxymethyl)morpholin-4-yl]-oxidanyl-phosphinothioyl]oxymethyl]-4-oxidanyl-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione, DICHLORO-ACETIC ACID, ... (4 entities in total)
• 機能のキーワード: complex, dinucleotide, inhibitor, ribonuclease, rnase, hydrolase
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33767.15

構造登録者

Dolot, R.,Jastrzebska, K.,Antonczyk, P. (登録日: 2023-11-17, 公開日: 2023-12-06, 最終更新日: 2024-11-20)

主引用文献

Jastrzebska, K.,Antonczyk, P.,Dolot, R.
P-Stereodefined morpholino dinucleoside 3',5'-phosphorothioates.
Org.Biomol.Chem., 22:8737-8742, 2024

PubMed Abstract: Here, we present for the first time the synthesis of P-stereodefined morpholino phosphorothioate analogs by using a modified 1,3,2-oxathiaphospholane method (OTP method) and provide valuable structural insights into their stereochemistry. -(2-Thio-4,4-pentamethylene-1,3,2-oxathiaphospholane) derivatives of morpholino-type nucleosides (U-OTPs) were synthesized, separated into pure P-diastereomers and used to prepare P-stereodefined morpholino dinucleoside 3',5'-phosphorothioates.

PubMed: 39392463
DOI: 10.1039/d4ob01437e

実験手法

X-RAY DIFFRACTION (1.8 Å)