8R4W
(3+1) hybrid-2 G-quadruplex with a -(llp) loop progression
Summary for 8R4W
| Entry DOI | 10.2210/pdb8r4w/pdb |
| NMR Information | BMRB: 34877 |
| Descriptor | DNA (25-MER) (1 entity in total) |
| Functional Keywords | g-quadruplex, hybrid-2, (3+1) hybrid, -(llp), dna |
| Biological source | synthetic construct |
| Total number of polymer chains | 1 |
| Total formula weight | 7906.08 |
| Authors | Jana, J.,Vianney, Y.M.,Weisz, K. (deposition date: 2023-11-14, release date: 2023-12-27, Last modification date: 2024-01-31) |
| Primary citation | Jana, J.,Vianney, Y.M.,Weisz, K. Impact of loop length and duplex extensions on the design of hybrid-type G-quadruplexes. Chem.Commun.(Camb.), 60:854-857, 2024 Cited by PubMed Abstract: A G-rich core sequence G-TCA-G-T-G-T-G can be designed to fold into a parallel or into two different (3+1) hybrid-type G-quadruplexes, among them an elusive topology with one lateral followed by two propeller loops. Favored folds can be rationalized based on the number of intervening thymidines and on additional complementary flanking sequences. PubMed: 38131370DOI: 10.1039/d3cc05625b PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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