8R4V

Structure of Salt-inducible kinase 3 in complex with inhibitor

8R4V の概要

• エントリーDOI: 10.2210/pdb8r4v/pdb
• 分子名称: Serine/threonine-protein kinase SIK3, 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]urea (3 entities in total)
• 機能のキーワード: kinase, ampk-like, uba, inhibitor complex, drug design, ligase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 115369.60

構造登録者

Kack, H.,Oster, L. (登録日: 2023-11-14, 公開日: 2024-03-27, 最終更新日: 2024-10-09)

• 主引用文献: Oster, L.,Castaldo, M.,de Vries, E.,Edfeldt, F.,Pemberton, N.,Gordon, E.,Cederblad, L.,Kack, H.; The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity.; J.Biol.Chem., 300:107201-107201, 2024; PubMed: 38508313; DOI: 10.1016/j.jbc.2024.107201

実験手法

X-RAY DIFFRACTION (1.9 Å)