8R4U

Structure of salt-inducible kinase 3 with inhibitors

Summary for 8R4U

Entry DOI	10.2210/pdb8r4u/pdb
Descriptor	Serine/threonine-protein kinase SIK3, scFvH1, 8-[(5-azanyl-1,3-dioxan-2-yl)methyl]-6-[2-chloranyl-4-(3-fluoranylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, ... (5 entities in total)
Functional Keywords	kinase, inhibitor complex, drug design, ampk-like kinase, uba, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	263571.46
Authors	Kack, H.,Oster, L. (deposition date: 2023-11-14, release date: 2024-03-27, Last modification date: 2024-05-08)
Primary citation	Oster, L.,Castaldo, M.,de Vries, E.,Edfeldt, F.,Pemberton, N.,Gordon, E.,Cederblad, L.,Kack, H. The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity. J.Biol.Chem., 300:107201-107201, 2024 Cited by PubMed: 38508313 DOI: 10.1016/j.jbc.2024.107201 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.416 Å)

Structure validation