8R4U
Structure of salt-inducible kinase 3 with inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Serine/threonine-protein kinase SIK3 | polymer | 328 | 37888.9 | 4 | UniProt (Q9Y2K2) Pfam (PF00069) | Homo sapiens (human) | |
| 2 | B, D, F, H (B, D, F, H) | scFvH1 | polymer | 265 | 27411.0 | 4 | Homo sapiens | ||
| 3 | I, L, M, O (A, C, E, G) | 8-[(5-azanyl-1,3-dioxan-2-yl)methyl]-6-[2-chloranyl-4-(3-fluoranylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | non-polymer | 496.9 | 4 | Chemie (XW3) | |||
| 4 | J, K, N, P (A, B, E, G) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 59 - 385 (UniProt: Q9Y2K2)
| PDB | External Database | Details |
|---|---|---|
| Ser 58 | - | expression tag |
| Ser 121 | Cys 121 | engineered mutation |
| Ser 181 | Cys 181 | engineered mutation |
| Ser 333 | Cys 333 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 261199.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2371.9 | |
| All* | Total formula weight | 263571.5 |
