8R36

Crystal structure of the Gluk1 ligand-binding domain in complex with kainate and BPAM538 at 1.90 A resolution

Summary for 8R36

• Entry DOI: 10.2210/pdb8r36/pdb
• Descriptor: Glutamate receptor ionotropic, kainate 1, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, SULFATE ION, ... (7 entities in total)
• Functional Keywords: ionotropic glutamate receptor, gluk1 ligand-binding domain, membrane protein, positive allosteric modulator, kainate
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 2
• Total formula weight: 60026.02

Authors

Bay, Y.,Frantsen, S.M.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2023-11-08, release date: 2024-08-14, Last modification date: 2024-09-04)

• Primary citation: Bay, Y.,Cabello, F.J.M.,Koens, C.C.,Frantsen, S.M.,Pickering, D.S.,Frydenvang, K.,Francotte, P.,Pirotte, B.,Kristensen, A.S.,Bowie, D.,Kastrup, J.S.; Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538.; J.Struct.Biol., 216:108113-108113, 2024; PubMed: 39079583; DOI: 10.1016/j.jsb.2024.108113

Experimental method

X-RAY DIFFRACTION (1.9 Å)