8R24

SARS-CoV-2 Mpro (Omicron, P132H+T169S) free enzyme

Summary for 8R24

Entry DOI	10.2210/pdb8r24/pdb
Descriptor	3C-like proteinase nsp5 (2 entities in total)
Functional Keywords	sars-cov-2; main protease; omicron; molecular dynamics; pro>his mutant; double mutant, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	1
Total formula weight	33852.55
Authors	Sun, X.,Ibrahim, M.,El Kilani, H.,Hilgenfeld, R. (deposition date: 2023-11-02, release date: 2024-11-13, Last modification date: 2025-04-09)
Primary citation	Ibrahim, M.,Sun, X.,Martins de Oliveira, V.,Liu, R.,Clayton, J.,El Kilani, H.,Shen, J.,Hilgenfeld, R. Why is the Omicron main protease of SARS-CoV-2 less stable than its wild-type counterpart? A crystallographic, biophysical, and theoretical study Hlife, 2:419-433, 2024 Cited by DOI: 10.1016/j.hlife.2024.06.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation