8R1L

Structure of avian H5N1 influenza A polymerase in complex with human ANP32B.

8R1L の概要

• エントリーDOI: 10.2210/pdb8r1l/pdb
• EMDBエントリー: 18822
• 分子名称: Acidic leucine-rich nuclear phosphoprotein 32 family member B, Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, ... (4 entities in total)
• 機能のキーワード: influenza virus, replication platform, h5n1, influenza adaptive mutations, host adaptation, viral polymerase, cryo-em, hpai., viral protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 299413.26

構造登録者

Carrique, L.,Staller, E.,Keown, J.R.,Fan, H.,Fodor, E.,Grimes, J.M. (登録日: 2023-11-02, 公開日: 2024-05-08, 最終更新日: 2024-05-29)

• 主引用文献: Staller, E.,Carrique, L.,Swann, O.C.,Fan, H.,Keown, J.R.,Sheppard, C.M.,Barclay, W.S.,Grimes, J.M.,Fodor, E.; Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation.; Nat Commun, 15:4123-4123, 2024; PubMed: 38750014; DOI: 10.1038/s41467-024-48470-3

実験手法

ELECTRON MICROSCOPY (3.1 Å)