8QZD

Soluble epoxide hydrolase in complex with Epoxykinin

8QZD の概要

• エントリーDOI: 10.2210/pdb8qzd/pdb
• 分子名称: Bifunctional epoxide hydrolase 2, 1,2-ETHANEDIOL, 2-[5-bromanyl-3-[2,2,2-tris(fluoranyl)ethanoyl]indol-1-yl]-N-cycloheptyl-ethanamide, ... (5 entities in total)
• 機能のキーワード: complex, structural genomics, structural genomics consortium, sgc, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43221.08

構造登録者

Kumar, A.,Ehrler, J.M.H.,Ziegler, S.,Doetsch, L.,Proschak, E.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2023-10-27, 公開日: 2024-02-28, 最終更新日: 2024-04-03)

• 主引用文献: Dotsch, L.,Davies, C.,Hennes, E.,Schonfeld, J.,Kumar, A.,Guita, C.D.C.L.,Ehrler, J.H.M.,Hiesinger, K.,Thavam, S.,Janning, P.,Sievers, S.,Knapp, S.,Proschak, E.,Ziegler, S.,Waldmann, H.; Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator.; J.Med.Chem., 67:4691-4706, 2024; PubMed: 38470246; DOI: 10.1021/acs.jmedchem.3c02245

実験手法

X-RAY DIFFRACTION (1.3 Å)