8QWM

Structure of p53 cancer mutant Y205C

Summary for 8QWM

• Entry DOI: 10.2210/pdb8qwm/pdb
• Descriptor: Cellular tumor antigen p53, ZINC ION, L(+)-TARTARIC ACID, ... (5 entities in total)
• Functional Keywords: tumor suppressor, transcription factor, cancer mutation, protein stability, conformational mutant, dna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 50045.27

Authors

Balourdas, D.I.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2023-10-19, release date: 2024-06-19)

• Primary citation: Balourdas, D.I.,Markl, A.M.,Kramer, A.,Settanni, G.,Joerger, A.C.; Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.; Cell Death Dis, 15:408-408, 2024; PubMed: 38862470; DOI: 10.1038/s41419-024-06739-x

Experimental method

X-RAY DIFFRACTION (1.54 Å)