8QSJ

Human mitoribosomal large subunit assembly intermediate 2 with GTPBP7

これはPDB形式変換不可エントリーです。

8QSJ の概要

• エントリーDOI: 10.2210/pdb8qsj/pdb
• 関連するPDBエントリー: 8PK0
• EMDBエントリー: 17719 17720 17721
• 分子名称: 39S ribosomal protein L32, mitochondrial, 39S ribosomal protein L41, mitochondrial, 16S rRNA, ... (64 entities in total)
• 機能のキーワード: mitochondria, maturation, biogenesis, ribosome, gtpbp7, mtg1, lsu
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 58
• 化学式量合計: 1932367.24

構造登録者

Ritter, C.,Nguyen, T.G.,Kummer, E. (登録日: 2023-10-10, 公開日: 2023-12-13, 最終更新日: 2024-06-26)

主引用文献

Nguyen, T.G.,Ritter, C.,Kummer, E.
Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.
Nat Commun, 14:7991-7991, 2023

PubMed Abstract: Mitochondria contain their own genetic information and a dedicated translation system to express it. The mitochondrial ribosome is assembled from mitochondrial-encoded RNA and nuclear-encoded ribosomal proteins. Assembly is coordinated in the mitochondrial matrix by biogenesis factors that transiently associate with the maturing particle. Here, we present a structural snapshot of a large mitoribosomal subunit assembly intermediate containing 7 biogenesis factors including the GTPases GTPBP7 and GTPBP10. Our structure illustrates how GTPBP10 aids the folding of the ribosomal RNA during the biogenesis process, how this process is related to bacterial ribosome biogenesis, and why mitochondria require two biogenesis factors in contrast to only one in bacteria.

PubMed: 38042949
DOI: 10.1038/s41467-023-43599-z

実験手法

ELECTRON MICROSCOPY (3 Å)