8QMC

High resolution structure of the Streptococcus pneumoniae topoisomerase IV-complex with the V-site 18mer dsDNA and novel fluoroquinolone Delafloxacin

Summary for 8QMC

• Entry DOI: 10.2210/pdb8qmc/pdb
• Related: 8C41
• Descriptor: DNA topoisomerase (ATP-hydrolyzing),DNA topoisomerase 4 subunit A, (4S)-2-METHYL-2,4-PENTANEDIOL, delafloxacin, ... (12 entities in total)
• Functional Keywords: protein-dna cleavage complex, topoisomerase iia, delafloxacin, topoisomerase iv-dna-antibiotic complex, isomerase
• Biological source: Streptococcus pneumoniae; More
• Total number of polymer chains: 6
• Total formula weight: 180905.76

Authors

Najmudin, S.,Pan, X.S.,Wang, B.,Chayen, N.E.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2023-09-21, release date: 2024-10-02)

• Primary citation: Najmudin, S.,Pan, X.S.,Wang, B.,Chayen, N.E.,Fisher, L.M.,Sanderson, M.R.; The nature of the molecular interactions at high resolution of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.402 Å)