8QMC
High resolution structure of the Streptococcus pneumoniae topoisomerase IV-complex with the V-site 18mer dsDNA and novel fluoroquinolone Delafloxacin
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG |
| Chain | Residue | Details |
| A | LEU431-GLY439 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_00937, ECO:0000269|PubMed:20596531 |
| Chain | Residue | Details |
| A | TYR1118 | |
| B | TYR1118 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | SITE: Interaction with DNA |
| Chain | Residue | Details |
| A | LYS1038 | |
| B | LYS1093 | |
| A | HIS1074 | |
| A | HIS1076 | |
| A | ARG1087 | |
| A | LYS1093 | |
| B | LYS1038 | |
| B | HIS1074 | |
| B | HIS1076 | |
| B | ARG1087 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer |
| Chain | Residue | Details |
| A | ARG1117 | |
| B | ARG1117 |
