8QMC

High resolution structure of the Streptococcus pneumoniae topoisomerase IV-complex with the V-site 18mer dsDNA and novel fluoroquinolone Delafloxacin

8QMC の概要

• エントリーDOI: 10.2210/pdb8qmc/pdb
• 関連するPDBエントリー: 8C41
• 分子名称: DNA topoisomerase (ATP-hydrolyzing),DNA topoisomerase 4 subunit A, (4S)-2-METHYL-2,4-PENTANEDIOL, delafloxacin, ... (12 entities in total)
• 機能のキーワード: protein-dna cleavage complex, topoisomerase iia, delafloxacin, topoisomerase iv-dna-antibiotic complex, isomerase
• 由来する生物種: Streptococcus pneumoniae; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 180905.76

構造登録者

Najmudin, S.,Pan, X.S.,Wang, B.,Chayen, N.E.,Fisher, L.M.,Sanderson, M.R. (登録日: 2023-09-21, 公開日: 2024-10-02)

• 主引用文献: Najmudin, S.,Pan, X.S.,Wang, B.,Chayen, N.E.,Fisher, L.M.,Sanderson, M.R.; The nature of the molecular interactions at high resolution of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin.; To Be Published,

実験手法

X-RAY DIFFRACTION (2.402 Å)