8QMB

Nucleant-assisted 2.0 A resolution structure of the Streptococcus pneumoniae topoisomerase IV-V18mer DNA complex with the novel fluoroquinolone Delafloxacin

Summary for 8QMB

• Entry DOI: 10.2210/pdb8qmb/pdb
• Related: 8C41
• Descriptor: DNA topoisomerase 4 subunit B,DNA topoisomerase 4 subunit A, ACETATE ION, FORMIC ACID, ... (13 entities in total)
• Functional Keywords: protein-dna cleavage complex, topoisomerase iia, delafloxacin, topoisomerase iv-dna-antibiotic complex, isomerase, pegylated graphene
• Biological source: Streptococcus pneumoniae; More
• Total number of polymer chains: 6
• Total formula weight: 181444.30

Authors

Najmudin, S.,Pan, X.S.,Wang, B.,Chayen, N.E.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2023-09-21, release date: 2024-10-02)

• Primary citation: Najmudin, S.,Pan, X.S.,Wang, B.,Chayen, N.E.,Fisher, L.M.,Sanderson, M.R.; The nature of the molecular interactions at high resolution of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)