8QLS

Human MST3 (STK24) kinase in complex with inhibitor MR26

Summary for 8QLS

Entry DOI	10.2210/pdb8qls/pdb
Descriptor	Serine/threonine-protein kinase 24, 8-(4-azanylbutyl)-6-[2-chloranyl-4-(6-methylpyridin-2-yl)phenyl]-2-(3-morpholin-4-ylpropylamino)pyrido[2,3-d]pyrimidin-7-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	selective kinase inhibitors, structure-guided drug design, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35804.50
Authors	Balourdas, D.I.,Rak, M.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2023-09-20, release date: 2023-11-08, Last modification date: 2024-06-19)
Primary citation	Rak, M.,Menge, A.,Tesch, R.,Berger, L.M.,Balourdas, D.I.,Shevchenko, E.,Kramer, A.,Elson, L.,Berger, B.T.,Abdi, I.,Wahl, L.M.,Poso, A.,Kaiser, A.,Hanke, T.,Kronenberger, T.,Joerger, A.C.,Muller, S.,Knapp, S. Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. J.Med.Chem., 67:3813-3842, 2024 Cited by PubMed: 38422480 DOI: 10.1021/acs.jmedchem.3c02217 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation