8QLR

Human MST3 (STK24) kinase in complex with inhibitor MR24

8QLR の概要

• エントリーDOI: 10.2210/pdb8qlr/pdb
• 分子名称: Serine/threonine-protein kinase 24, 8-(4-azanylbutyl)-2-[1,3-bis(oxidanyl)propan-2-ylamino]-6-[2-chloranyl-4-(6-methylpyridin-2-yl)phenyl]pyrido[2,3-d]pyrimidin-7-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: selective kinase inhibitors, structure-guided drug design, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70323.50

構造登録者

Balourdas, D.I.,Rak, M.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (登録日: 2023-09-20, 公開日: 2023-11-08, 最終更新日: 2024-06-19)

• 主引用文献: Rak, M.,Menge, A.,Tesch, R.,Berger, L.M.,Balourdas, D.I.,Shevchenko, E.,Kramer, A.,Elson, L.,Berger, B.T.,Abdi, I.,Wahl, L.M.,Poso, A.,Kaiser, A.,Hanke, T.,Kronenberger, T.,Joerger, A.C.,Muller, S.,Knapp, S.; Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors.; J.Med.Chem., 67:3813-3842, 2024; PubMed: 38422480; DOI: 10.1021/acs.jmedchem.3c02217

実験手法

X-RAY DIFFRACTION (1.85 Å)