8QKB
Crystal structure of human cathepsin L in complex with the vinyl sulfone inhibitor K777
Summary for 8QKB
Entry DOI | 10.2210/pdb8qkb/pdb |
Related | 8OZA 8PRX |
Descriptor | Cathepsin L, NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE, TETRAETHYLENE GLYCOL, ... (8 entities in total) |
Functional Keywords | cystein protease, drug target, lysosome, virus cell entry, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 101342.66 |
Authors | Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2023-09-14, release date: 2023-09-27, Last modification date: 2024-05-22) |
Primary citation | Falke, S.,Lieske, J.,Herrmann, A.,Loboda, J.,Karnicar, K.,Gunther, S.,Reinke, P.Y.A.,Ewert, W.,Usenik, A.,Lindic, N.,Sekirnik, A.,Dretnik, K.,Tsuge, H.,Turk, V.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A. Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 67:7048-7067, 2024 Cited by PubMed: 38630165DOI: 10.1021/acs.jmedchem.3c02351 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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