8QKB
Crystal structure of human cathepsin L in complex with the vinyl sulfone inhibitor K777
Summary for 8QKB
Entry DOI | 10.2210/pdb8qkb/pdb |
Related | 8OZA 8PRX |
Descriptor | Cathepsin L, NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE, TETRAETHYLENE GLYCOL, ... (8 entities in total) |
Functional Keywords | cystein protease, drug target, lysosome, virus cell entry, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 101342.66 |
Authors | Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2023-09-14, release date: 2023-09-27) |
Primary citation | Falke, S.,Lieske, J.,Herrmann, A.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A. Crystal structure of human cathepsin L in complex with the vinyl sulfone inhibitor K777 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report