8QJZ

Crystal structure of E. coli LpxH in complex with lipid X

8QJZ の概要

• エントリーDOI: 10.2210/pdb8qjz/pdb
• 分子名称: UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, ... (4 entities in total)
• 機能のキーワード: lipid a biosynthesis pathway endotoxin udp-diacyl-glucosamine lipid x gram-negative bacteria lipopolysaccharides hydrolase, hydrolase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28684.94

構造登録者

Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (登録日: 2023-09-14, 公開日: 2024-04-17)

• 主引用文献: Huseby, D.L.,Cao, S.,Zamaratski, E.,Sooriyaarachchi, S.,Ahmad, S.,Bergfors, T.,Krasnova, L.,Pelss, J.,Ikaunieks, M.,Loza, E.,Katkevics, M.,Bobileva, O.,Cirule, H.,Gukalova, B.,Grinberga, S.,Backlund, M.,Simoff, I.,Leber, A.T.,Berruga-Fernandez, T.,Antonov, D.,Konda, V.R.,Lindstrom, S.,Olanders, G.,Brandt, P.,Baranczewski, P.,Vingsbo Lundberg, C.,Liepinsh, E.,Suna, E.,Jones, T.A.,Mowbray, S.L.,Hughes, D.,Karlen, A.; Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.; Proc.Natl.Acad.Sci.USA, 121:e2317274121-e2317274121, 2024; PubMed: 38579010; DOI: 10.1073/pnas.2317274121

実験手法

X-RAY DIFFRACTION (1.35 Å)