8QGY
Cryo-EM structure of C-terminally truncated Apoptosis signal-regulating kinase 1 (ASK1)
Summary for 8QGY
Entry DOI | 10.2210/pdb8qgy/pdb |
EMDB information | 18396 |
Descriptor | Mitogen-activated protein kinase kinase kinase 5 (1 entity in total) |
Functional Keywords | ask1, map3k, mapk signaling, thioredoxin, apoptosis |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 203817.25 |
Authors | Kosek, D.,Honzejkova, K.,Obsilova, V.,Obsil, T. (deposition date: 2023-09-06, release date: 2024-04-03) |
Primary citation | Honzejkova, K.,Kosek, D.,Obsilova, V.,Obsil, T. The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1. Elife, 13:-, 2024 Cited by PubMed: 38536085DOI: 10.7554/eLife.95199 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.71 Å) |
Structure validation
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